Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL792539 | 0.91 | DRD3 (0.41) | ALDH1A1MAPTSMN1; SMN2HTR2AHTR2C | |
| SCHEMBL792524 | 0.81 | FABP4 (0.45) | ALDH1A1SMN1; SMN2HTR2AHTR2CHPGD | |
| SCHEMBL792496 | 0.72 | GAA (0.41) | ALDH1A1MAPTHTR2AHTR2CHPGD | |
| SCHEMBL792516 | 0.70 | HTR7 (0.34) | ALDH1A1MAPTHPGDFABP4 | |
| SCHEMBL792527 | 0.69 | ALDH1A1 (0.41) | ALDH1A1MAPTSMN1; SMN2HTR2AHTR2C | |
| SCHEMBL3604547 | 0.67 | ALDH1A1 (0.49) | ALDH1A1MAPTSMN1; SMN2HTR2AHPGD | |
| SCHEMBL5310198 | 0.66 | HDAC6 (0.54) | ALDH1A1MAPTSMN1; SMN2SIGMAR1KMT2A | |
| SCHEMBL1305865 | 0.66 | DRD2 (0.65) | ALDH1A1MAPTSMN1; SMN2SIGMAR1KMT2A | |
| SCHEMBL8242491 | 0.65 | MTNR1B (0.45) | ALDH1A1MAPTSMN1; SMN2HPGDHCAR3 | |
| Hydrochloric Acid SCHEMBL1841012 | 0.65 | DRD2 (0.63) | ALDH1A1MAPTSMN1; SMN2SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | JAPAN TOBACCO INC. (JP) | 2012-03-22 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049593-A1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | POLI, TERT, ZC3HAV1 | ALDH1A1 750/4885MAPT 3389/4885SMN1; SMN2 4306/4885 |
| US-20120070409-A1 | TETRACYCLIC FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR | POLI, TERT, ZC3HAV1 | ALDH1A1 750/4885MAPT 3389/4885SMN1; SMN2 4306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.