Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LONP1 | P36776 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 2/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982855 | 0.77 | TGFBR1 (0.31) | LONP1TGFBR1 | |
| SCHEMBL7478743 | 0.73 | MMP2 (0.39) | RENMMP2MMP3 | |
| SCHEMBL6983469 | 0.70 | PPARG (0.33) | TGFBR1MMP2 | |
| SCHEMBL6982036 | 0.70 | BMP1 (0.32) | TGFBR1MMP2 | |
| SCHEMBL7928682 | 0.69 | EPHX2 (0.35) | REN | |
| SCHEMBL4290067 | 0.69 | MMP2 (0.41) | MMP2MMP3 | |
| SCHEMBL6984617 | 0.68 | MMP2 (0.33) | RENMMP2MMP3 | |
| SCHEMBL6980503 | 0.68 | TGFBR1 (0.35) | TGFBR1 | |
| SCHEMBL6988228 | 0.67 | TGFBR1 (0.30) | TGFBR1 | |
| SCHEMBL6942324 | 0.67 | CREBBP (0.31) | TGFBR1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |