Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.33 |
| ▸ | MMP3 | P08254 | 5/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.32 |
| ▸ | REN | P00797 | 4/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6984895 | 0.73 | CTSC (0.33) | — | |
| SCHEMBL4290067 | 0.73 | MMP2 (0.41) | MMP2MMP3FKBP1AMMP1EPHX2 | |
| SCHEMBL7478743 | 0.72 | MMP2 (0.39) | MMP2MMP3FKBP1AMMP1REN | |
| SCHEMBL7840445 | 0.69 | MMP1 (0.46) | MMP2MMP3MMP1EPHX2 | |
| SCHEMBL7840440 | 0.69 | LMNA (0.40) | MMP2MMP3MMP1EPHX2 | |
| SCHEMBL7928679 | 0.68 | LONP1 (0.33) | MMP2MMP3REN | |
| SCHEMBL5020595 | 0.67 | HDAC1 (0.48) | — | |
| SCHEMBL4287736 | 0.67 | EPHX2 (0.40) | MMP2MMP3FKBP1AEPHX2 | |
| SCHEMBL6983815 | 0.66 | MMP1 (0.41) | MMP2MMP3MMP1EPHX2 | |
| SCHEMBL9836588 | 0.66 | EPHX2 (0.54) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089964-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-10-29 | — | — | EP | disclosed |
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |
| EP-1089964-A1 | HYDRAZINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000000465-A1 | HYDRAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2000-01-06 | — | — | WO | disclosed |