Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.34 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PTAFR | P25105 | 3/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.32 |
| ▸ | REN | P00797 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982858 | 0.73 | MMP1 (0.38) | FKBP1ACTSLCTSBPTAFRREN | |
| SCHEMBL4290067 | 0.71 | MMP2 (0.41) | EPHX2FKBP1A | |
| SCHEMBL7840445 | 0.71 | MMP1 (0.46) | EPHX2 | |
| SCHEMBL7840440 | 0.70 | LMNA (0.40) | EPHX2 | |
| SCHEMBL7848831 | 0.70 | ADRA1B (0.33) | FKBP1ACYP1A2CYP2C9 | |
| SCHEMBL7928679 | 0.69 | LONP1 (0.33) | REN | |
| SCHEMBL7478743 | 0.69 | MMP2 (0.39) | FKBP1AREN | |
| SCHEMBL6983470 | 0.68 | BMP1 (0.39) | CTSLCTSBREN | |
| SCHEMBL6983815 | 0.68 | MMP1 (0.41) | EPHX2CYP1A2 | |
| SCHEMBL9836588 | 0.67 | EPHX2 (0.54) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6239151-B1 | TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES, OSTEOARTHRITIS, RESPIRATORY DISEASES, TUMORS, CACHEXIA, CARDIOVASCULAR DISEASES, FEVER, HAEMORRHAGE AND SEPSIS, HYDRAZINE DERIVATIVES, | HOFFMANN-LA ROCHE INC. | 2001-05-29 | — | — | US | disclosed |