SCHEMBL7930833

SCHEMBL7930833

CO[Si](C)(OC)c1ccccc1.CO[Si](OC)(c1ccc(C)cc1)c1ccc(C)cc1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.36
LMNA P02545 1/20 0.36
TSHR P16473 1/20 0.36
ALOX12 P18054 1/20 0.36
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
HPGD P15428 2/20 0.35
NFKB1 P19838 2/20 0.35
NFKB2 Q00653 2/20 0.35
RELA Q04206 2/20 0.35
POLB P06746 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
TDP1 Q9NUW8 2/20 0.32
CASP3 P42574 1/20 0.31
SENP8 Q96LD8 1/20 0.31
SENP7 Q9BQF6 1/20 0.31
SENP6 Q9GZR1 1/20 0.31
CES2 O00748 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3481943 0.90 ACHE (0.43) ACHELMNATSHRALOX12NPC1
SCHEMBL384790 0.84 ACHE (0.42) ACHELMNATSHRNPC1RAB9A
SCHEMBL5549084 0.83 ESR1 (0.31) POLBESR1ESR2
SCHEMBL706592 0.82 ESR1 (0.41) ACHELMNATSHRALOX12POLB
SCHEMBL297138 0.82 ACHE (0.44) ACHETSHRNPC1RAB9ARELA
SCHEMBL49103 0.82 ESR1 (0.41) ACHELMNATSHRALOX12NPC1
SCHEMBL9505641 0.80 ESR1 (0.39) TSHRNPC1RAB9AHPGDPOLB
SCHEMBL49008 0.79 CA4 (0.41) ACHELMNATSHRALOX12NPC1
SCHEMBL27596877 0.79 CA4 (0.41) ACHELMNATSHRALOX12NPC1
SCHEMBL6853999 0.79 ALDH1A1 (0.38) ACHELMNATSHRALOX12NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6323150-B1 CONTACTING LIQUID MAGNESIUM COMPOUNDS WITH A LIQUID TITANIUM COMPOUND TO PRECIPITATE A SOLID; REACTING WITH AN ELECTRON DONOR WHICH IS A POLYCARBOXYLIC ESTER OR A COMPOUND HAVING TWO OR MORE ETHER LINKAGES MITSUI CHEMICALS, INC. (JP) 2001-11-27 US disclosed
EP-0259124-A2 Method of polymerizing alpha olefins MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1988-03-09 EP disclosed