SCHEMBL7931191

SCHEMBL7931191

COC(=O)C1=Cc2cc(-c3ccc(C)s3)ccc2S(=O)(=O)CC1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.35
HDAC2 Q92769 3/20 0.35
HDAC3 O15379 2/20 0.35
TNFRSF1A P19438 3/20 0.34
PGR P06401 1/20 0.34
CNR1 P21554 2/20 0.33
ERN1 O75460 1/20 0.32
DRD2 P14416 1/20 0.32
HTR2A P28223 1/20 0.32
HTR2C P28335 1/20 0.32
DRD3 P35462 1/20 0.32
HTR6 P50406 1/20 0.32
CA12 O43570 4/20 0.32
CA9 Q16790 4/20 0.32
IKBKB O14920 1/20 0.31
TP53 P04637 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CA2 P00918 1/20 0.30
ALDH1A1 P00352 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7931232 0.88 HDAC2 (0.35) HDAC1HDAC2HDAC3PGRCNR1
SCHEMBL7971803 0.88 PGR (0.36) HDAC1HDAC2HDAC3TNFRSF1APGR
SCHEMBL7969815 0.84 HDAC1 (0.36) HDAC1HDAC2HDAC3TNFRSF1ACA12
SCHEMBL7975083 0.83 CA12 (0.39) CA12CA9CA2ALDH1A1POLB
SCHEMBL7934057 0.81 SLC6A3 (0.40) CA12CA9IKBKBSMN1; SMN2ALDH1A1
SCHEMBL7969052 0.80 CA12 (0.42) CNR1CA12CA9SMN1; SMN2CA2
SCHEMBL7969353 0.80 SLC6A3 (0.40) CA12CA9TP53SMN1; SMN2CA2
SCHEMBL7934163 0.80 KDM4E (0.45) CA12CA9SMN1; SMN2CA2ALDH1A1
SCHEMBL7969661 0.79 PTGDR2 (0.41) CA12CA9CA2
SCHEMBL7934116 0.79 CTSL (0.39) CA12CA9SMN1; SMN2ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1140896-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 Takeda Chemical Industries, Ltd. (JP) 2001-10-10 EP disclosed
US-6235771-B1 AIDS THERPAY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-05-22 US disclosed
WO-2000037455-A1 BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-06-29 WO disclosed