Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ACACA | Q13085 | 7/20 | 0.36 |
| ▸ | ACACB | O00763 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928473 | 0.96 | ALPL (0.43) | PLA2G2AALPLGAAMAPT | |
| SCHEMBL7975157 | 0.94 | RARB (0.40) | PLA2G2AALPLPOLBKDM4EMAPT | |
| SCHEMBL7922057 | 0.92 | MAPT (0.42) | KDM4EALDH1A1GAAHPGDMAPT | |
| SCHEMBL7968606 | 0.91 | MAPT (0.36) | ALPLACACBKDM4EALDH1A1GAA | |
| SCHEMBL7246973 | 0.91 | KCNH2 (0.39) | MAPK1SMN1; SMN2ACACBPOLBTSHR | |
| SCHEMBL7216635 | 0.90 | LTA4H (0.39) | PLA2G2AALPLMAPK1SMN1; SMN2ACACA | |
| SCHEMBL7252964 | 0.89 | RARB (0.40) | MAPK1SMN1; SMN2ACACAACACBTSHR | |
| SCHEMBL7934163 | 0.87 | KDM4E (0.45) | ALPLSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL7221547 | 0.86 | LMNA (0.40) | MAPK1SMN1; SMN2ACACBALDH1A1CASP1 | |
| SCHEMBL7934116 | 0.86 | CTSL (0.39) | SMN1; SMN2POLBTSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140896-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | Takeda Chemical Industries, Ltd. (JP) | 2001-10-10 | — | — | EP | disclosed |
| US-6235771-B1 | AIDS THERPAY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-22 | — | — | US | disclosed |
| WO-2000037455-A1 | BENZOTHIEPIN-ANILIDE DERIVATIVES, THEIR PRODUCTION AND THEIR USE FOR ANTAGONIZING CCR-5 | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-06-29 | — | — | WO | disclosed |