SCHEMBL7935873

SCHEMBL7935873

COc1cccc2c1C(C(=O)O)C(=O)CC2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.43
MTNR1B P49286 4/20 0.43
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
HTR1A P08908 3/20 0.42
HCRTR1 O43613 3/20 0.40
HCRTR2 O43614 3/20 0.40
CETP P11597 1/20 0.40
CYP2D6 P10635 1/20 0.39
DRD2 P14416 2/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.39
POLB P06746 1/20 0.39
MAPT P10636 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7935755 0.87 HTR1A (0.52) MTNR1AMTNR1BCA1CA2HTR1A
SCHEMBL9372184 0.80 HTR2A (0.42) MTNR1AMTNR1BHTR1AHCRTR1HCRTR2
SCHEMBL9052842 0.80 DRD2 (0.45) HTR1AHCRTR1HCRTR2DRD2
SCHEMBL7214403 0.77 PIN1 (0.52) MTNR1AMTNR1BCA1CA2HTR1A
SCHEMBL8900041 0.76 HTR1A (0.43) MTNR1AMTNR1BHTR1ACYP2D6CYP1A2
SCHEMBL22837450 0.75 CETP (0.46) HTR1ACETPDRD2
SCHEMBL20478656 0.75 DRD4 (0.50) MTNR1AMTNR1BHTR1AHCRTR1HCRTR2
SCHEMBL9457823 0.74 HTR1A (0.51) MTNR1AMTNR1BCA1CA2HTR1A
SCHEMBL9457826 0.74 HTR1A (0.51) MTNR1AMTNR1BCA1CA2HTR1A
SCHEMBL9457829 0.74 HTR1A (0.51) MTNR1AMTNR1BCA1CA2HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6331636-B1 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL THE UPJOHN COMPANY 2001-12-18 US disclosed
US-5545755-A USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE THE UPJOHN COMPANY (US) 1996-08-13 US disclosed
US-5389687-A Selective antagonists of serotonin ELI LILLY AND COMPANY (US) 1995-02-14 US disclosed
EP-0476016-A1 THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES PHARMACIA & UPJOHN COMPANY (US) 1992-03-25 EP disclosed
WO-1990015047-A1 THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES THE UPJOHN COMPANY (US) 1990-12-13 WO disclosed