Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 10/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7935873 | 0.80 | MTNR1A (0.43) | DRD2HTR1AHCRTR1HCRTR2 | |
| SCHEMBL7935755 | 0.78 | HTR1A (0.52) | HTR1AACHE | |
| SCHEMBL21360734 | 0.78 | BRD4 (0.38) | ACHEHCRTR2 | |
| SCHEMBL7926754 | 0.76 | HTR1A (0.55) | DRD2HTR1AHCRTR1HCRTR2 | |
| SCHEMBL9341290 | 0.76 | HTR2C (0.49) | HTR1A | |
| SCHEMBL8874693 | 0.76 | PDE7A (0.35) | — | |
| SCHEMBL22837450 | 0.75 | CETP (0.46) | DRD2HTR1A | |
| SCHEMBL7926523 | 0.75 | HTR1A (0.53) | DRD2HTR1A | |
| SCHEMBL9372184 | 0.75 | HTR2A (0.42) | DRD2HTR1AHCRTR1HCRTR2 | |
| SCHEMBL8900041 | 0.74 | HTR1A (0.43) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996007656-A1 | CIS-HEXAHYDRO-5-(2-NAPHTHALENYL)PYRROLO<3,4-c>PYRROLES | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5457121-A | Cis-hexahydro-5-(1,2,3,4-tetrahydro-2-naphthalenyl)pyrrolo<3,4-c>pyrroles as inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0343830-B1 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | LILLY CO ELI (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5026707-A | Antiserotonine agents | ELI LILLY AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| EP-0343830-A2 | Ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes | ELI LILLY AND COMPANY (US) | 1989-11-29 | — | — | EP | disclosed |