Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.40 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.40 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.39 |
| ▸ | RRM1 | P23921 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7947948 | 0.94 | KMT2A (0.41) | KMT2AMEN1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL7944266 | 0.85 | ANPEP (0.52) | ALDH1A1SMN1; SMN2HPGDANPEPDNPEP | |
| SCHEMBL29300401 | 0.85 | LMNA (0.46) | KMT2AMEN1ALDH1A1GNAI3GNAO1 | |
| SCHEMBL14682812 | 0.84 | KMT2A (0.45) | KMT2AMEN1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18313728 | 0.83 | ALDH1A1 (0.52) | KMT2AMEN1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL29237467 | 0.83 | CASP2 (0.47) | KMT2AMEN1ALDH1A1SMN1; SMN2GNAI3 | |
| SCHEMBL20813199 | 0.83 | HPGD (0.54) | ALDH1A1HPGDANPEPDNPEPCASP2 | |
| SCHEMBL16853212 | 0.82 | ALDH1A1 (0.55) | KMT2AMEN1ALDH1A1SMN1; SMN2PAOX | |
| SCHEMBL17740189 | 0.82 | SLC6A5 (0.55) | ALDH1A1SMN1; SMN2GNAI3GNAO1GNAI1 | |
| SCHEMBL24692521 | 0.82 | SMN1; SMN2 (0.58) | KMT2AMEN1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584748-B2 | Spirocyclic compounds | C4 THERAPEUTICS, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210032245-A1 | SPIROCYCLIC COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | US | disclosed |
| US-20100003276-A1 | Methods for treating anthrax and inhibiting lethal factor | HERMES JEFFERY D | 2010-01-07 | — | — | US | disclosed |
| US-7504425-B2 | Compounds useful in the treatment of anthrax and inhibiting lethal factor | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003276-A1 | Methods for treating anthrax and inhibiting lethal factor | ANTXR2, SERPINB1, APAF1 | KMT2A 4071/4885MEN1 2618/4885ALDH1A1 4088/4885 |
| US-20210032245-A1 | SPIROCYCLIC COMPOUNDS | CRBN, RBX1, XIAP | KMT2A 1849/4885MEN1 1561/4885ALDH1A1 2000/4885 |
| US-11584748-B2 | Spirocyclic compounds | CRBN, RBX1, XIAP | KMT2A 1849/4885MEN1 1561/4885ALDH1A1 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.