Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7928892 | 0.78 | KDM4E (0.49) | CRHR1KDM4EALDH1A1HPGDCDK4 | |
| SCHEMBL14752628 | 0.77 | MEN1 (0.43) | KDM4EALDH1A1HPGDTSHRKDM5A | |
| SCHEMBL7937098 | 0.74 | CRHR1 (0.46) | CRHR1KDM4EALDH1A1HPGDCDK4 | |
| SCHEMBL7935049 | 0.71 | CRHR1 (0.47) | CRHR1LMNAMAPTTDP1L3MBTL1 | |
| SCHEMBL8122423 | 0.71 | CRHR1 (0.55) | CRHR1KDM4EALDH1A1HPGDCDK4 | |
| SCHEMBL7935053 | 0.70 | ALDH1A1 (0.50) | CRHR1KDM4EALDH1A1HPGDCDK4 | |
| SCHEMBL7961654 | 0.70 | CRHR1 (0.54) | CRHR1KDM4EALDH1A1HPGDCDK4 | |
| SCHEMBL5599498 | 0.68 | CRHR1 (0.72) | CRHR1TDP1 | |
| SCHEMBL6053303 | 0.68 | CRHR1 (0.52) | CRHR1KDM4EALDH1A1HPGDCDK4 | |
| SCHEMBL7937131 | 0.67 | CRHR1 (0.50) | CRHR1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6248753-B1 | CORTICOTROPIN-RELEASING FACTOR (CRF) ANTAGONISTS | PFIZER INC | 2001-06-19 | — | — | US | disclosed |
| EP-0765327-B1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0765327-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995034563-A1 | PYRAZOLO AND PYRROLOPYRIDINES | PFIZER INC. (US) | 1995-12-21 | — | — | WO | disclosed |