Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAPDH | P04406 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8732840 | 0.95 | GAPDH (0.53) | GAPDHLMNACYP3A4ADORA2AACHE | |
| SCHEMBL8734451 | 0.95 | GAPDH (0.53) | GAPDHLMNACYP3A4ADORA2AACHE | |
| SCHEMBL5045934 | 0.87 | CA12 (0.49) | GAPDHLMNACYP3A4ACHEMAPT | |
| SCHEMBL7937480 | 0.81 | CYP1A2 (0.46) | CYP3A4TDP1NPC1RAB9A | |
| SCHEMBL28032593 | 0.74 | LMNA (0.66) | GAPDHLMNACYP3A4ADORA2AACHE | |
| SCHEMBL30595409 | 0.73 | CA12 (0.65) | LMNACYP3A4ACHEMAPTTDP1 | |
| SCHEMBL3974361 | 0.73 | CA12 (0.65) | LMNACYP3A4ACHEMAPTTDP1 | |
| SCHEMBL4607313 | 0.73 | LMNA (0.71) | GAPDHLMNACYP3A4ACHEMAPT | |
| SCHEMBL4289002 | 0.71 | LMNA (0.46) | GAPDHLMNACYP3A4ADORA2AACHE | |
| SCHEMBL4446422 | 0.71 | MAPT (0.67) | LMNACYP3A4ACHEMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826680-A1 | Dihydronaphthalene and naphthalene compounds, intermediates, formulations, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |