Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.40 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | KLK1 | P06870 | 2/20 | 0.38 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940421 | 0.89 | KDR (0.48) | PLAUMTNR1BMTNR1AKDRPLG | |
| SCHEMBL7940509 | 0.86 | MTNR1B (0.50) | PLAUMTNR1BMTNR1APLGKLK1 | |
| SCHEMBL7937755 | 0.84 | FGFR1 (0.44) | PLAUMTNR1BMTNR1ARXFP1KDR | |
| SCHEMBL7940489 | 0.83 | MTNR1A (0.48) | PLAUMTNR1BMTNR1AKDRMEN1 | |
| SCHEMBL7937164 | 0.82 | MTNR1B (0.47) | PLAUMTNR1BKDRMEN1KMT2A | |
| SCHEMBL8501413 | 0.81 | AKR1C3 (0.42) | MTNR1BMTNR1AAKR1C3AKR1C2ESR1 | |
| SCHEMBL7187740 | 0.80 | FFAR1 (0.50) | AKR1C3AKR1C2ESR1 | |
| SCHEMBL7935128 | 0.79 | MTNR1B (0.49) | PLAUMTNR1BMTNR1APOLBPLG | |
| SCHEMBL7928746 | 0.79 | DHFR (0.41) | ESR1ESR2MEN1KMT2A | |
| SCHEMBL7928830 | 0.79 | PLAU (0.47) | PLAUMTNR1BMTNR1AKDRPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835868-B1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | LILLY CO ELI (US) | 2001-08-29 | — | — | EP | disclosed |
| US-5929090-A | NOVEL COMPOUNDS FOR TREATING ESTROGEN DEPRIVATION CAUSED BY MENOPAUSE OR OVARIECTOMY; TREATING OSTEOPOROSIS, CARDIOVASCULAR DISEASES, AND ENDOMETRIOSIS | ELI LILLY AND COMPANY (US) | 1999-07-27 | — | — | US | disclosed |
| EP-0835868-A1 | 2-Aryl-3-aminoaryloxynaphthyl compounds, intermediates, compositions and methods | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |