Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7933040 | 0.89 | ENPP3 (0.32) | ENPP3ENPP1KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL4482816 | 0.87 | KDM1A (0.33) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL3765255 | 0.87 | KDM1A (0.33) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL2114523 | 0.79 | DHFR (0.36) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL216563 | 0.76 | ENPP3 (0.33) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7212490 | 0.76 | ALDH1A1 (0.33) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7933100 | 0.76 | KDM1A (0.33) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL7926729 | 0.76 | ALDH1A1 (0.33) | KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL7938957 | 0.75 | KDM4E (0.33) | ENPP3ENPP1KDM1AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL218691 | 0.75 | ENPP3 (0.31) | ENPP3ENPP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184402-B1 | RESOLUTION OF A STEREOISOMERIC MIXTURE OF SPECIFIC METALLOCENE COMPLEXES BRIDGED WITH A TRANSITION METAL HAVING AN OXYGEN BOND ATTACHED, I.E., A MU-OXO COMPLEX; HYDROLYSIS IN THE PRESENCE OF A BASE; SEPARATION OF MESO FORM FROM MIXES | CHISSO CORPORATION (JP) | 2001-02-06 | — | — | US | disclosed |