Hydrochloric Acid

Hydrochloric Acid

SCHEMBL216563

CC1=C(c2cccc3ccccc23)c2ccccc2C1[Hf+2](C1C(C)=C(c2cccc3ccccc23)c2ccccc21)[SiH](C)C.[Cl-].[Cl-]

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 1/20 0.33
ENPP1 P22413 1/20 0.33
ALDH1A1 P00352 6/20 0.33
CYP2A6 P11509 1/20 0.33
MAPT P10636 4/20 0.32
NPC1 O15118 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
RAB9A P51151 1/20 0.32
DHFR P00374 1/20 0.32
KDM4E B2RXH2 5/20 0.31
HPGD P15428 4/20 0.31
MAPK1 P28482 2/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
TDP2 O95551 1/20 0.31
ALOX12 P18054 1/20 0.31
CASP3 P42574 1/20 0.31
HTT P42858 1/20 0.31
GALK1 P51570 1/20 0.31
BLM P54132 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL218691 0.87 ENPP3 (0.31) ENPP3ENPP1ALDH1A1KDM4EHPGD
Hydrochloric Acid SCHEMBL218939 0.86 ALDH1A1 (0.33) ALDH1A1CYP2A6MAPTNPC1SMN1; SMN2
Hydrochloric Acid SCHEMBL2114523 0.83 DHFR (0.36) ENPP3ENPP1ALDH1A1CYP2A6MAPT
Hydrochloric Acid SCHEMBL7212490 0.81 ALDH1A1 (0.33) ENPP3ENPP1ALDH1A1CYP2A6MAPT
Hydrochloric Acid SCHEMBL3765255 0.81 KDM1A (0.33) ENPP3ENPP1ALDH1A1CYP2A6MAPT
Hydrochloric Acid SCHEMBL4482816 0.81 KDM1A (0.33) ENPP3ENPP1ALDH1A1CYP2A6MAPT
Hydrochloric Acid SCHEMBL7933100 0.81 KDM1A (0.33) ENPP3ENPP1ALDH1A1CYP2A6MAPT
Hydrochloric Acid SCHEMBL7933040 0.77 ENPP3 (0.32) ENPP3ENPP1ALDH1A1CYP2A6DHFR
Hydrochloric Acid SCHEMBL7926729 0.77 ALDH1A1 (0.33) ALDH1A1CYP2A6DHFRKDM4EHPGD
Hydrochloric Acid SCHEMBL7939134 0.76 ENPP3 (0.31) ENPP3ENPP1ALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015065784-A1 NOVEL ALUMINUM ALKYL WITH C5 CYCLIC AND PENDENT OLEFIN POLYMERIZATION CATALYST EXXONMOBIL CHEMICAL PATENTS INC. (US) 2015-05-07 WO claimed
US-20150119540-A1 Novel Aluminum Alkyl With C5 Cyclic and Pendent Olefin Polymerization Catalyst EXXONMOBIL CHEMICAL PATENTS INC. 2015-04-30 US claimed
EP-1799726-B1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEM PATENTS INC (US) 2011-07-13 EP claimed
US-7741417-B2 Preparation of polymerization catalyst activators utilizing indole-modified silica supports EXXONMOBIL CHEMICAL PATENTS INC. (US) 2010-06-22 US claimed
US-7385015-B2 Trialkylaluminum treated supports EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-06-10 US claimed
EP-1799726-A1 TRIALKYLALUMINUM TREATED SUPPORTS Exxonmobil Chemical Patents Inc. (US) 2007-06-27 EP claimed
US-20070055028-A1 Preparation of polymerization catalyst activators utilizing indole-modified silica supports EXXONMOBIL CHEMICAL PATENTS INC. 2007-03-08 US claimed
WO-2006044058-A1 TRIALKYLALUMINUM TREATED SUPPORTS EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-04-27 WO claimed
US-10676547-B2 Aluminum alkyls with pendant olefins on clays EXXONMOBIL CHEMICAL PATENTS INC. (US) 2020-06-09 US disclosed
EP-2064248-B1 PREPARATION OF POLYMERIZATION CATALYST ACTIVATORS UTILIZING INDOLE-MODIFIED SILICA SUPPORTS EXXONMOBIL CHEMICAL PATENTS INC (US) 2018-10-10 EP disclosed
US-10059788-B2 Organoaluminum activators on clays EXXONMOBIL CHEMICAL PATENTS INC. (US) 2018-08-28 US disclosed
US-20180201700-A1 Aluminum Alkyls with Pendant Olefins on Clays EXXONMOBIL CHEMICAL PATENTS INC. 2018-07-19 US disclosed
EP-3344385-A1 ALUMINUM ALKYLS WITH PENDANT OLEFINS ON CLAYS ExxonMobil Chemical Patents Inc. (US) 2018-07-11 EP disclosed
US-20170313799-A1 Organoaluminum Activators on Clays EXXONMOBIL CHEMICAL PATENTS INC. 2017-11-02 US disclosed
US-7037989-B2 Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-05-02 US disclosed
WO-2005113622-A1 MULTIPLE CATALYST AND REACTOR SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-12-01 WO disclosed
EP-1558655-A2 MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM Exxonmobil Chemical Patents Inc. (US) 2005-08-03 EP disclosed
US-20040220359-A1 Multiple catalyst and reactor system for olefin polymerization and polymers produced therefrom EXXONMOBIL CHEMICAL PATENTS INC. 2004-11-04 US disclosed
US-20040138392-A1 polyolefin adhesives; to produce reactor blends (also called intimate blends) of various polymers and other polymer compositions. EXXONMOBIL CHEMICAL PATENTS INC. 2004-07-15 US disclosed
WO-2004046214-A2 MULTIPLE CATALYST SYSTEM FOR OLEFIN POLYMERIZATION AND POLYMERS PRODUCED THEREFROM EXXONMOBIL CHEMICAL PATENTS INC. (US) 2004-06-03 WO disclosed