Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL5347437 | 0.83 | GPR3 (0.32) | — | |
| Hydrochloric Acid SCHEMBL3661444 | 0.81 | GPR3 (0.33) | — | |
| Hydrochloric Acid SCHEMBL9412848 | 0.79 | NR3C1 (0.39) | MEN1ALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL7641203 | 0.74 | — | — | |
| Methane SCHEMBL7939292 | 0.73 | MTNR1A (0.32) | MEN1ALDH1A1MAPTRAB9AKMT2A | |
| Methane SCHEMBL6559545 | 0.72 | KDM1A (0.32) | KDM1A | |
| Hydrochloric Acid SCHEMBL7603013 | 0.72 | MEN1 (0.31) | MEN1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7940430 | 0.72 | MEN1 (0.31) | MEN1ALDH1A1MAPTRAB9AKMT2A | |
| Hydrochloric Acid SCHEMBL7605151 | 0.71 | KDM4E (0.30) | ALDH1A1 | |
| SCHEMBL7604535 | 0.71 | ALDH1A1 (0.32) | MEN1ALDH1A1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123938-A2 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 2001-08-16 | — | — | EP | disclosed |
| EP-0672675-A1 | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5451649-A | Organometallic fluorenyl compounds, preparation, and use | PHILLIPS PETROLEUM COMPANY (US) | 1995-09-19 | — | — | US | disclosed |