Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30141079 | 0.93 | HPGD (0.57) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL24983859 | 0.93 | HPGD (0.57) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL2788605 | 0.92 | LMNA (0.55) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL28633934 | 0.90 | KDM4E (0.56) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL22015349 | 0.88 | TDP1 (0.62) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL2719972 | 0.87 | LMNA (0.56) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL2338199 | 0.86 | HPGD (0.76) | LMNAHPGDALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL13287192 | 0.86 | HPGD (0.55) | LMNAHPGDSMN1; SMN2KDM4E | |
| SCHEMBL289420 | 0.86 | KMT2A (0.60) | KMT2ATDP1SLC6A2SLC6A3LMNA | |
| SCHEMBL793724 | 0.85 | MEN1 (0.65) | KMT2ALMNAHPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110305102-B | 1, 3-benzodioxole natural polyphenolic acid ester compound and application thereof in reducing blood fat | 陕西中医药大学 | 2020-11-24 | — | — | CN | disclosed |
| US-9517993-B2 | Antagonists of the toll-like receptor 1/2 complex | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-09-10 | — | — | US | disclosed |
| EP-2879669-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | The Regents of The University of Colorado, A Body Corporate (US) | 2015-06-10 | — | — | EP | disclosed |
| US-8901317-B2 | Tryptamine derivatives, their preparation and their use in gastropathy | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2014-12-02 | — | — | US | disclosed |
| WO-2014022287-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2014-02-06 | — | — | WO | disclosed |
| US-20130197052-A1 | TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN GASTROPATHY | UNIVERSITY OF CALCUTTA (IN) | 2013-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150251987-A1 | ANTAGONISTS OF THE TOLL-LIKE RECEPTOR 1/2 COMPLEX | TLR2, TLR1, TLR3 | KMT2A 2587/4885TDP1 1568/4885SLC6A2 4242/4885 |
| US-20130197052-A1 | TRYPTAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN GASTROPATHY | HTRA2, AIFM1, SI | KMT2A 3725/4885TDP1 1458/4885SLC6A2 605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.