SCHEMBL7944337

SCHEMBL7944337

C=CCNC1=NS(=O)(=O)c2ccc(Cl)cc2N1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.42
CYP1A2 P05177 3/20 0.42
CYP3A4 P08684 3/20 0.42
ALDH1A1 P00352 2/20 0.42
LMNA P02545 2/20 0.42
CYP2D6 P10635 2/20 0.42
THRB P10828 1/20 0.42
TSHR P16473 1/20 0.42
ABCC8 Q09428 1/20 0.42
KCNJ11 Q14654 1/20 0.42
HTR1A P08908 1/20 0.36
HPGD P15428 3/20 0.36
MAPT P10636 2/20 0.36
KDM4E B2RXH2 1/20 0.36
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
CYP2C19 P33261 2/20 0.35
POLB P06746 1/20 0.35
TAAR1 Q96RJ0 1/20 0.35
CXCR2 P25025 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7952129 0.91 ALDH1A1 (0.53) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL6553744 0.82 CA12 (0.49) SMN1; SMN2ALDH1A1LMNAMAPTKDM4E
SCHEMBL7952180 0.79 THRB (0.45) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL7957197 0.79 SMN1; SMN2 (0.42) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL7952139 0.79 THRB (0.45) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL24050254 0.78 TAAR1 (0.45) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL7951206 0.78 CYP1A2 (0.44) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL7950744 0.78 TAAR1 (0.41) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL7952799 0.78 ABCC8 (0.44) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA
SCHEMBL7952406 0.77 HTT (0.43) SMN1; SMN2CYP1A2CYP3A4ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12209140-B2 Therapeutics for the treatment of glaucoma MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2025-01-28 US disclosed
US-20230219912-A1 HALOGENATED BENZOTHIADIAZINES FOR THE TREATMENT OF CANCER NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-07-13 US disclosed
US-20230101009-A1 THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2023-03-30 US disclosed
US-11505572-B2 Therapeutics for the treatment of glaucoma MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2022-11-22 US disclosed
WO-2021236818-A1 HALOGENATED BENZOTHIADIAZINES FOR THE TREATMENT OF CANCER BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) 2021-11-25 WO disclosed
US-10981951-B2 Therapeutics for the treatment of glaucoma MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2021-04-20 US disclosed
US-20210040148-A1 THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2021-02-11 US disclosed
US-20170002040-A1 NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2017-01-05 US disclosed
US-6242443-B1 1,2,4-benzothiadiazine derivatives, their preparation and use NOVO NORDISK AIS (DK) 2001-06-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219912-A1 HALOGENATED BENZOTHIADIAZINES FOR THE TREATMENT OF CANCER TFAM, NDUFAF1, NDUFV1 SMN1; SMN2 4586/4885CYP1A2 536/4885CYP3A4 1002/4885
US-20230101009-A1 THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA KCNJ1, KCNJ2, KCNJ11 SMN1; SMN2 3539/4885CYP1A2 2573/4885CYP3A4 1886/4885
US-20210040148-A1 THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA KCNJ1, KCNJ2, KCNJ11 SMN1; SMN2 3539/4885CYP1A2 2573/4885CYP3A4 1886/4885
US-12209140-B2 Therapeutics for the treatment of glaucoma KCNJ1, KCNJ2, KCNJ11 SMN1; SMN2 3539/4885CYP1A2 2573/4885CYP3A4 1886/4885
US-20170002040-A1 NOVEL THERAPEUTICS FOR THE TREATMENT OF GLAUCOMA KCNJ1, KCNK4, KCNK2 SMN1; SMN2 3361/4885CYP1A2 3097/4885CYP3A4 2080/4885
US-11505572-B2 Therapeutics for the treatment of glaucoma KCNJ1, KCNJ2, KCNJ11 SMN1; SMN2 3539/4885CYP1A2 2573/4885CYP3A4 1886/4885
US-10981951-B2 Therapeutics for the treatment of glaucoma KCNJ1, KCNJ2, KCNJ11 SMN1; SMN2 3539/4885CYP1A2 2573/4885CYP3A4 1886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.