Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.56 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.56 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.56 |
| ▸ | CHRNG | P07510 | 4/20 | 0.56 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.56 |
| ▸ | CHRND | Q07001 | 4/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811754 | 0.98 | ALDH1A1 (0.61) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL17644179 | 0.86 | SLC6A3 (0.65) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL895863 | 0.86 | SLC6A3 (0.65) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL5954545 | 0.84 | SLC6A3 (0.66) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL17645636 | 0.84 | SLC6A3 (0.63) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL9597385 | 0.84 | SLC6A3 (0.61) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL11037118 | 0.84 | SLC6A2 (0.67) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL28360223 | 0.84 | SLC6A2 (0.67) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| Hydrochloric Acid SCHEMBL9596538 | 0.83 | SLC6A3 (0.60) | SLC6A3SLC6A2KDM4EALDH1A1GAA | |
| SCHEMBL9360364 | 0.83 | SLC6A3 (0.60) | SLC6A3SLC6A2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258827-B1 | HYDROXYAROMATIC HETEROCYCLIC ALKANOLS AND LEVODOPA | PFIZER INC. | 2001-07-10 | — | — | US | disclosed |
| EP-0828513-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1998-03-18 | — | — | EP | disclosed |
| CN-1159325-A | Co-therapy for Parkinson's syndrome | PFIZER (US) | 1997-09-17 | — | — | CN | disclosed |
| WO-1996037226-A2 | COMBINATIONS FOR THE TREATMENT OF PARKINSONISM CONTAINING SELECTIVE NMDA ANTAGONISTS | PFIZER INC. (US) | 1996-11-28 | — | — | WO | disclosed |