Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357010 | 0.88 | GRIK1 (0.47) | ELANESMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL7354860 | 0.86 | GRIK1 (0.47) | ELANESMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL7354439 | 0.84 | CYP1A2 (0.48) | CYP1A2MAPTKDM4EALDH1A1GAA | |
| SCHEMBL7474077 | 0.80 | SERPINE1 (0.51) | ELANESMN1; SMN2MAPTNOD2NOD1 | |
| SCHEMBL27583602 | 0.74 | MAPT (0.51) | SMN1; SMN2MAPTALDH1A1KMT2ANPSR1 | |
| SCHEMBL26633067 | 0.72 | CYP1A2 (0.64) | CYP1A2SMN1; SMN2MAPTKDM4EALDH1A1 | |
| SCHEMBL7349744 | 0.72 | GRIK1 (0.45) | ALDH1A1MEN1KMT2A | |
| SCHEMBL6019085 | 0.72 | NOD2 (0.50) | ELANEMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL2827166 | 0.72 | ALDH1A1 (0.44) | SMN1; SMN2MAPTALDH1A1KMT2ANPSR1 | |
| SCHEMBL7361149 | 0.71 | SMN1; SMN2 (0.51) | CYP1A2ELANESMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | claimed |
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |