Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | MC5R | P33032 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949245 | 0.82 | BRD4 (0.39) | HDAC1HDAC6ACKR3CYP3A4OPRM1 | |
| SCHEMBL7949797 | 0.80 | F2 (0.34) | F2ACKR3CYP3A4CYP2D6OPRM1 | |
| SCHEMBL7947145 | 0.80 | F2 (0.34) | F2ACKR3CYP3A4CYP2D6OPRM1 | |
| SCHEMBL7986076 | 0.80 | HDAC1 (0.36) | PKMHDAC1HDAC6F2CYP2D6 | |
| SCHEMBL7945088 | 0.78 | HDAC1 (0.38) | HDAC1HDAC6F2CYP2D6OPRM1 | |
| SCHEMBL7944087 | 0.77 | BCHE (0.37) | PKMHDAC1HDAC6CYP2D6OPRM1 | |
| SCHEMBL13896765 | 0.77 | MEN1 (0.41) | ACKR3 | |
| SCHEMBL7969135 | 0.76 | BCHE (0.38) | F2ACKR3CYP2D6 | |
| SCHEMBL7944573 | 0.75 | TDP1 (0.37) | CYP2D6OPRM1OPRD1OPRK1 | |
| SCHEMBL7947592 | 0.74 | RAB9A (0.36) | F2ACKR3CYP2D6CXCR4OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |