Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7945088 | 0.95 | HDAC1 (0.38) | BCHEEGFRHDAC1HDAC6OPRM1 | |
| SCHEMBL7986076 | 0.88 | HDAC1 (0.36) | BCHEEGFRHDAC1HDAC6KCNH2 | |
| SCHEMBL7947592 | 0.81 | RAB9A (0.36) | BCHEOPRM1OPRD1KCNH2CYP2D6 | |
| SCHEMBL7969135 | 0.80 | BCHE (0.38) | BCHEKCNH2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL7949581 | 0.80 | CXCR4 (0.38) | BCHEHDAC6EPHX2HDAC2EPHX1 | |
| SCHEMBL7944573 | 0.79 | TDP1 (0.37) | BCHEOPRM1OPRD1KCNH2CYP2D6 | |
| SCHEMBL7947140 | 0.77 | PKM (0.37) | HDAC1HDAC6OPRM1OPRD1CYP2D6 | |
| SCHEMBL7946321 | 0.75 | TERT (0.37) | BCHEPKM | |
| SCHEMBL7938770 | 0.75 | L3MBTL1 (0.38) | KCNH2SLC6A2SLC6A4 | |
| SCHEMBL7992034 | 0.75 | F2 (0.33) | BCHEKCNH2CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |