Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
| ▸ | F12 | P00748 | 3/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7946321 | 0.84 | TERT (0.37) | BCHEACKR3 | |
| SCHEMBL7945088 | 0.82 | HDAC1 (0.38) | RAB9ACYP2D6KCNH2SLC6A2SLC6A4 | |
| SCHEMBL7944087 | 0.81 | BCHE (0.37) | CYP2D6KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7986076 | 0.80 | HDAC1 (0.36) | CYP2D6KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7969135 | 0.76 | BCHE (0.38) | RAB9ACYP2D6KCNH2SLC6A2SLC6A4 | |
| SCHEMBL7944573 | 0.75 | TDP1 (0.37) | CYP2D6KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7938073 | 0.74 | HRH3 (0.37) | CYP2D6PRMT5WDR77 | |
| SCHEMBL7947140 | 0.74 | PKM (0.37) | CYP2D6CXCR4ACKR3F2OPRM1 | |
| SCHEMBL7937873 | 0.73 | HTR2A (0.41) | HTR2A | |
| SCHEMBL7949581 | 0.73 | CXCR4 (0.38) | CXCR4BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |