Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5087314 | 0.83 | PNMT (0.38) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL8676755 | 0.80 | PNMT (0.35) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL4447246 | 0.74 | DRD2 (0.38) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL2837143 | 0.71 | PNMT (0.35) | PNMTDRD2DRD4DRD3NPC1 | |
| Biphenyl SCHEMBL27411999 | 0.70 | DRD2 (0.35) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL27407138 | 0.70 | PGR (0.42) | PNMTDRD2DRD4DRD3NPC1 | |
| SCHEMBL3157956 | 0.69 | PNMT (0.35) | PNMTDRD2DRD4DRD3NPC1 | |
| Hydrochloric Acid SCHEMBL676211 | 0.68 | NPC1 (0.36) | PNMTNPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7201361 | 0.66 | KDM4E (0.51) | PNMTDRD2DRD3NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL27407140 | 0.66 | NPC1 (0.41) | PNMTDRD2DRD4DRD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245870-B1 | INTRODUCING SELECTED METALLOCENE CATALYST AND ALUMOXANE COCATALYST INTO POLYMERIZATION REACTION ZONE CONTAINING OLEFIN MONOMER, MAINTAINING REACTION ZONE UNDER POLYMERIZATION REACTION CONDITIONS, EXTRACTING SYNDIOTACTIC/ISOTACTIC BLOCK | FINA TECHNOLOGY, INC. | 2001-06-12 | — | — | US | disclosed |
| EP-0747406-B1 | Process for producing syndiotactic/isotactic block polyolefins | FINA TECHNOLOGY (US) | 1998-10-07 | — | — | EP | disclosed |
| EP-0747406-A1 | Process for producing syndiotactic/isotactic block polyolefins | FINA TECHNOLOGY, INC. (US) | 1996-12-11 | — | — | EP | disclosed |