Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 13/20 | 0.85 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6312814 | 0.81 | SLC6A9 (0.70) | OPRL1SLC6A9KCNH2MAPK1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL7803563 | 0.71 | SLC6A9 (0.68) | OPRL1SLC6A9KCNH2HTR6RAB9A | |
| Hydrochloric Acid SCHEMBL7803562 | 0.71 | SLC6A9 (0.68) | OPRL1SLC6A9KCNH2HTR6RAB9A | |
| SCHEMBL7951589 | 0.67 | KMT2A (0.51) | OPRL1NPC1 | |
| SCHEMBL7953606 | 0.67 | OPRL1 (0.50) | OPRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7813281 | 0.67 | SLC6A9 (0.96) | OPRL1SLC6A9KCNH2 | |
| SCHEMBL6306617 | 0.67 | OPRL1 (0.59) | OPRL1SLC6A9KCNH2MAPK1L3MBTL1 | |
| SCHEMBL8780726 | 0.67 | SLC6A9 (0.56) | OPRL1SLC6A9KCNH2MAPK1NPC1 | |
| SCHEMBL9054446 | 0.66 | HTR1A (0.47) | OPRL1MAPK1HTR6HTTKDM4E | |
| SCHEMBL17100793 | 0.65 | HTR6 (0.45) | MAPK1L3MBTL1NPC1HTR6HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
| EP-0773942-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003400-A1 | 4-INDOLE DERIVATIVES AS SEROTONIN AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-02-08 | — | — | WO | disclosed |