Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 4/20 | 0.39 |
| ▸ | MMP13 | P45452 | 4/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP12 | P39900 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | MMP16 | P51512 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7696804 | 0.84 | BMP1 (0.43) | MMP9MMP13MMP1MMP2MMP12 | |
| SCHEMBL6929547 | 0.81 | MMP7 (0.52) | MMP9MMP1MMP2MMP14HDAC8 | |
| SCHEMBL7394460 | 0.77 | MMP9 (0.37) | PLCG1MMP9MMP13MMP1MMP2 | |
| SCHEMBL6932142 | 0.77 | MMP9 (0.51) | MMP9MMP13MMP1MMP2CA1 | |
| SCHEMBL6934202 | 0.72 | MMP13 (0.53) | MMP9MMP13MMP1MMP2MMP12 | |
| SCHEMBL4432528 | 0.64 | CA1 (0.52) | PLCG1CA1CA2CA4CA6 | |
| SCHEMBL15918007 | 0.64 | CA2 (0.52) | PLCG1CA1CA2CA4CA6 | |
| SCHEMBL7324090 | 0.64 | MMP13 (0.71) | MMP9MMP13MMP1MMP2MMP12 | |
| SCHEMBL1800130 | 0.63 | CA1 (0.56) | PLCG1CA1CA2CA4CA6 | |
| SCHEMBL1767645 | 0.63 | CA1 (0.56) | PLCG1MMP9MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331563-B1 | LOW MOLECULAR WEIGHT, NON-PEPTIDE INHIBITORS OF MATRIX METALLOPROTEINASES AND TUMOR NECROSIS FACTOR-ALPHA CONVERTING ENZYME; TREATING ARTHRITIS, TUMOR METASTASIS, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, INSULIN RESISTANCE | WYETH HOLDINGS CORPORATION | 2001-12-18 | — | — | US | disclosed |