Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.62 |
| ▸ | ATP4B | P51164 | 3/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15095108 | 0.91 | ATP4A (0.62) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL903268 | 0.90 | ATP4A (0.65) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL11914458 | 0.90 | ATP4A (0.61) | ATP4AATP4BHTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL3702932 | 0.89 | ATP4A (0.64) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL8322317 | 0.83 | ADRA2A (0.44) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL7964742 | 0.83 | CYP1A2 (0.44) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL8321782 | 0.81 | CYP1A2 (0.42) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL11066583 | 0.80 | ATP4A (0.77) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13925634 | 0.80 | ATP4A (0.62) | ATP4AATP4BHTR1ADRD2HTR2A | |
| SCHEMBL2193469 | 0.79 | ATP4A (0.76) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110293889-A1 | NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE | MSN LABORATORIES LIMITED (IN) | 2011-12-01 | — | — | US | claimed |
| EP-2300467-A2 | NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE | MSN Laboratories Limited (IN) | 2011-03-30 | — | — | EP | claimed |
| US-20100311969-A1 | Process For Preparation of Paliperidone | Watson Pharma Private Limited (IN) | 2010-12-09 | — | — | US | claimed |
| US-20100298566-A1 | PROCESS FOR THE PREPARATION OF PALIPERIDONE AND ITS INTERMEDIATES | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2010-11-25 | — | — | US | claimed |
| EP-2249649-A2 | AN IMPROVED PROCESS FOR PREPARATION OF PALIPERIDONE | Watson Pharma Private Limited (IN) | 2010-11-17 | — | — | EP | claimed |
| WO-2010004578-A2 | NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE | MSN LABORATORIES LIMITED (IN) | 2010-01-14 | — | — | WO | claimed |
| WO-2009116071-A2 | AN IMPROVED PROCESS FOR PREPARATION OF PALIPERIDONE | Watson Pharma Private Limited (IN) | 2009-09-24 | — | — | WO | claimed |
| WO-2009060297-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF PALIPERIDONE AND ITS INTERMEDIATES | ORCHID CHEMICALS & PHARMACEUTICALS LIMITED (IN) | 2009-05-14 | — | — | WO | claimed |
| EP-2046790-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | Teva Pharmaceutical Industries Ltd. (IL) | 2009-04-15 | — | — | EP | claimed |
| WO-2009045489-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP, A PALIPERIDONE INTERMEDIATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-04-09 | — | — | WO | claimed |
| WO-2008140646-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-11-20 | — | — | WO | claimed |
| US-20080214809-A1 | Process for the synthesis of CMHTP and intermediates thereof | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-09-04 | — | — | US | claimed |
| US-20080200676-A1 | Process for the synthesis of CMHTP and intermediates thereof | TEVA PHARMACEUTICALS USA, INC. | 2008-08-21 | — | — | US | claimed |
| EP-1924583-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | Teva Pharmaceutical Industries Ltd. (IL) | 2008-05-28 | — | — | EP | claimed |
| WO-2008024415-A2 | PROCESS FOR THE SYNTHESIS OF CMHTP AND INTERMEDIATES THEREOF | TEVA PHARMACEUTICAL INSUSTRIES LTD. (IL) | 2008-02-28 | — | — | WO | claimed |
| US-11667666-B2 | Methods and compositions for treatment of cancer | CFD RESEARCH CORPORATION (US) | 2023-06-06 | — | — | US | disclosed |
| CN-106132956-B | Heterocyclic compound, preparation method and application thereof | 中国科学院上海药物研究所 | 2019-12-10 | — | — | CN | disclosed |
| EP-0368388-B1 | 3-Piperidinyl-1,2-benzisoxazoles | JANSSEN PHARMACEUTICA NV (BE) | 1995-05-10 | — | — | EP | disclosed |
| US-5254556-A | Antipsychotic; paliperidone palmitate | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-10-19 | — | — | US | disclosed |
| US-5158952-A | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214809-A1 | Process for the synthesis of CMHTP and intermediates thereof | HAMP, TPMT, MPHOSPH6 | ATP4A 2239/4885ATP4B 1984/4885HTR1A 13/4885 |
| US-20080200676-A1 | Process for the synthesis of CMHTP and intermediates thereof | HAMP, DHPS, MPHOSPH6 | ATP4A 3023/4885ATP4B 2716/4885HTR1A 13/4885 |
| US-11667666-B2 | Methods and compositions for treatment of cancer | TEK, VHL, TIE1 | ATP4A 3949/4885ATP4B 3928/4885HTR1A 3214/4885 |
| US-20100298566-A1 | PROCESS FOR THE PREPARATION OF PALIPERIDONE AND ITS INTERMEDIATES | AVPR2, AVPR1A, AVPR1B | ATP4A 3381/4885ATP4B 3612/4885HTR1A 70/4885 |
| US-20100311969-A1 | Process For Preparation of Paliperidone | FIP1L1, HTR3C, HTR4 | ATP4A 4190/4885ATP4B 3934/4885HTR1A 4/4885 |
| US-20110293889-A1 | NOVEL AND IMPROVED PROCESSES FOR THE PREPARATION OF PALIPERIDONE | AVPR2, AVPR1B, AVPR1A | ATP4A 3411/4885ATP4B 3330/4885HTR1A 24/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.