Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046362 | 0.84 | HDAC1 (0.51) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL7049001 | 0.79 | SMN1; SMN2 (0.45) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL7047270 | 0.78 | MAPT (0.48) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL7050361 | 0.77 | TSHR (0.43) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL7969831 | 0.77 | MAPT (0.47) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL7158730 | 0.75 | RAB9A (0.46) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL23422191 | 0.73 | LMNA (0.58) | LMNAMAPTRAB9AGAAHTT | |
| SCHEMBL7048477 | 0.73 | TP53 (0.40) | LMNAMAPTRAB9ASMN1; SMN2GAA | |
| SCHEMBL6595452 | 0.71 | ABCB11 (0.56) | LMNAMAPTSMN1; SMN2GAAHTT | |
| SCHEMBL5213680 | 0.70 | CCR2 (0.65) | LMNAMAPTSMN1; SMN2GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291507-B1 | INHIBITOR OF MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDOLE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |