Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12498707 | 0.80 | HSD11B1 (0.44) | EPHX2PPARGTBXAS1AKR1C3CYP3A4 | |
| SCHEMBL12498711 | 0.80 | HSD11B1 (0.44) | EPHX2PPARGTBXAS1AKR1C3CYP3A4 | |
| SCHEMBL7922173 | 0.79 | KDM4E (0.35) | EPHX2PPARGTBXAS1KDM4EKMT2A | |
| SCHEMBL24587500 | 0.78 | ALDH1A1 (0.44) | EPHX2PPARGTBXAS1AKR1C3CYP3A4 | |
| SCHEMBL11829415 | 0.78 | NFKB1 (0.46) | TBXAS1CYP3A4CYP2C9KDM4ELMNA | |
| SCHEMBL7947844 | 0.78 | ALDH1A1 (0.44) | EPHX2PPARGTBXAS1AKR1C3CYP3A4 | |
| SCHEMBL3377294 | 0.77 | CYP1A2 (0.50) | EPHX2PPARGTBXAS1CYP3A4CYP2C9 | |
| SCHEMBL16795914 | 0.77 | TRPA1 (0.47) | TBXAS1LMNAKMT2A | |
| SCHEMBL9390821 | 0.77 | TRPA1 (0.47) | TBXAS1LMNAKMT2A | |
| SCHEMBL5179024 | 0.77 | TBXAS1 (0.40) | EPHX2PPARGTBXAS1AKR1C3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211197-B1 | CARBOXYLIC ACID OR TETRAZOLE DERIVATES; ANALGESICS, ANTIPYRETICS, AND ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA & CO. (CA) | 2001-04-03 | — | — | US | disclosed |