Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9394292 | 0.80 | HTR7 (0.48) | OPRM1HTR7ADRA1AHRH3DRD2 | |
| SCHEMBL9396649 | 0.75 | ADRA1D (0.43) | OPRM1HTR7ADRA1AHRH3HTR1A | |
| SCHEMBL11740559 | 0.70 | ADRA1A (0.57) | OPRM1HTR7ADRA1ASIGMAR1DRD4 | |
| SCHEMBL6859239 | 0.70 | FFAR4 (0.46) | OPRM1ADRA1A | |
| SCHEMBL22660216 | 0.69 | HDAC1 (0.43) | ADRA1AHTR2AOPRK1ADRA2AADRA2B | |
| SCHEMBL11744408 | 0.69 | OPRM1 (0.56) | OPRM1HTR7ADRA1ASIGMAR1DRD4 | |
| SCHEMBL6862763 | 0.69 | HDAC1 (0.49) | — | |
| SCHEMBL28337704 | 0.68 | CYP2D6 (0.47) | OPRM1ADRA1AHTR2AHTR2BOPRK1 | |
| SCHEMBL6195779 | 0.68 | SIGMAR1 (0.57) | OPRM1HTR7ADRA1ASIGMAR1DRD4 | |
| SCHEMBL11747588 | 0.68 | OPRM1 (0.59) | OPRM1HTR7ADRA1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211198-B1 | BENIGN PROSTATE HYPERPLASIA; INTRAOCULAR PRESSURE; HYPOTENSIVE AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-04-03 | — | — | US | disclosed |