Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955926 | 0.92 | TNF (0.47) | KMT2AL3MBTL1KDM4EMAPTMAPK1 | |
| SCHEMBL7947029 | 0.82 | FABP4 (0.49) | KMT2AL3MBTL1MEN1GLAFABP4 | |
| SCHEMBL7955768 | 0.80 | DYRK1A (0.42) | KMT2AL3MBTL1MEN1GLAFABP4 | |
| SCHEMBL6595112 | 0.77 | CCR2 (0.59) | KDM4EMAPTALDH1A1MAPK1TDP1 | |
| SCHEMBL7961092 | 0.76 | F10 (0.55) | KMT2AMEN1GLAFABP4FABP5 | |
| SCHEMBL7839309 | 0.76 | CCR2 (0.57) | KDM4EMAPTALDH1A1MAPK1TDP1 | |
| SCHEMBL7956149 | 0.73 | L3MBTL1 (0.47) | L3MBTL1KDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL7086770 | 0.73 | ABCB11 (0.48) | KMT2AKDM4EMAPTALDH1A1MAPK1 | |
| SCHEMBL7954481 | 0.72 | TNF (0.43) | L3MBTL1PLA2G2AKDM4EMAPTALDH1A1 | |
| SCHEMBL703225 | 0.71 | ALDH1A1 (0.50) | L3MBTL1KDM4EMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6271251-B1 | CARDIOVASCULAR DISORDERS | SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) | 2001-08-07 | — | — | US | disclosed |
| US-5977100-A | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5834454-A | TREATMENT OF ANGINA, ISCHEMIA, ARRHYTHMIA | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-11-10 | — | — | US | disclosed |
| EP-0787728-A1 | Substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-08-06 | — | — | EP | disclosed |