Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.37 |
| ▸ | TYMS | P04818 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968952 | 0.82 | KDM4E (0.38) | DHFRCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL7956310 | 0.80 | DHFR (0.44) | DHFRTYMSCYP1A2KDM4EALDH1A1 | |
| SCHEMBL7983353 | 0.77 | CHRNA1 (0.42) | DHFRCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL7984718 | 0.77 | CHRNA1 (0.42) | DHFRCYP1A2KDM4EALDH1A1HPGD | |
| SCHEMBL7956293 | 0.76 | TLR8 (0.39) | CYP1A2CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL6026165 | 0.76 | HSD17B1 (0.38) | ALDH1A1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL6026628 | 0.76 | MEN1 (0.37) | CYP1A2ALDH1A1HTTTSHRMEN1 | |
| SCHEMBL6926535 | 0.73 | HCAR2 (0.49) | CYP1A2KDM4EHPGDMEN1KMT2A | |
| SCHEMBL7956291 | 0.73 | PTGER3 (0.40) | CYP1A2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7965561 | 0.72 | PTGS2 (0.43) | ALDH1A1HPGDSMN1; SMN2TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265436-B1 | ANTIINFLAMMATORY AGENTS | OXIS THERAPEUTICS INC. | 2001-07-24 | — | — | US | disclosed |