Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12078320 | 0.80 | NAMPT (0.69) | — | |
| SCHEMBL7011026 | 0.80 | TSHR (0.74) | KMT2APOLBIDO1PKMTSHR | |
| SCHEMBL1876581 | 0.76 | IDO1 (0.70) | POLBIDO1TSHRCYP2C19SMN1; SMN2 | |
| SCHEMBL6986513 | 0.75 | ADRA1A (0.51) | KMT2ASMN1; SMN2 | |
| SCHEMBL7956237 | 0.75 | GAA (0.44) | KMT2APOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL432382 | 0.73 | PKM (0.73) | KMT2APOLBIDO1PKMTSHR | |
| SCHEMBL5002972 | 0.72 | ALDH1A1 (0.53) | KMT2APOLBPKMALDH1A1HTT | |
| SCHEMBL18725052 | 0.71 | KEAP1 (0.71) | POLBIDO1CYP2C19CYP1A2CYP3A4 | |
| SCHEMBL7011029 | 0.71 | NAMPT (0.57) | POLBIDO1PKMTSHRCYP2C19 | |
| SCHEMBL6987038 | 0.71 | USP2 (0.67) | KMT2ATSHRALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324999-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002030927-A1 | NOVEL AMINOPHENYL PIPERAZINE OR AMINOPHENYL PIPERIDINE DERIVATIVES INHIBITING PRENYL TRANSFERASE PROTEINS AND METHODS FOR PREPARING SAME | PIERRE FABRE MEDICAMENT (FR) | 2002-04-18 | — | — | WO | disclosed |