Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | HTR2A | P28223 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.48 |
| ▸ | DRD1 | P21728 | 3/20 | 0.48 |
| ▸ | DRD5 | P21918 | 3/20 | 0.48 |
| ▸ | HRH1 | P35367 | 4/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | UBE2N | P61088 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949256 | 0.99 | THRB (0.47) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7949455 | 0.89 | MAPK1 (0.46) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7963618 | 0.89 | SIGMAR1 (0.51) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7957292 | 0.88 | SIGMAR1 (0.52) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7949350 | 0.88 | SIGMAR1 (0.50) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7967634 | 0.80 | HTR1A (0.51) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7957534 | 0.73 | DRD3 (0.58) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL8011318 | 0.72 | DRD2 (0.69) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7963783 | 0.71 | DRD2 (0.48) | HTR1ADRD2HTR2ADRD3SIGMAR1 | |
| SCHEMBL7960226 | 0.70 | DRD2 (0.47) | HTR1ADRD2HTR2ADRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | claimed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |