Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.51 |
| ▸ | DRD2 | P14416 | 10/20 | 0.51 |
| ▸ | DRD3 | P35462 | 10/20 | 0.51 |
| ▸ | HTR2A | P28223 | 9/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
| ▸ | DRD1 | P21728 | 3/20 | 0.51 |
| ▸ | DRD5 | P21918 | 3/20 | 0.51 |
| ▸ | HRH1 | P35367 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8600561 | 0.88 | MAPT (0.47) | HTR1ADRD2DRD3SIGMAR1HRH1 | |
| SCHEMBL8599796 | 0.88 | SIGMAR1 (0.56) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL7957460 | 0.80 | HTR1A (0.48) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL7949256 | 0.79 | THRB (0.47) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL8011318 | 0.75 | DRD2 (0.69) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL5179345 | 0.71 | ADRA1B (0.60) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL7957534 | 0.71 | DRD3 (0.58) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL7653085 | 0.70 | CYP2D6 (0.70) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL28918989 | 0.70 | DRD2 (0.58) | HTR1ADRD2DRD3HTR2ATMEM97 | |
| SCHEMBL10661045 | 0.70 | DRD2 (0.58) | HTR1ADRD2DRD3HTR2ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |