Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.58 |
| ▸ | DRD3 | P35462 | 7/20 | 0.58 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA2 | P00918 | 4/20 | 0.55 |
| ▸ | ACHE | P22303 | 4/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL629692 | 0.93 | DRD2 (0.66) | DRD2DRD3CYP26A1CA1CA2 | |
| SCHEMBL4001498 | 0.93 | DRD2 (0.66) | DRD2DRD3CYP26A1CA1CA2 | |
| SCHEMBL6403014 | 0.93 | DRD2 (0.66) | DRD2DRD3CYP26A1CA1CA2 | |
| SCHEMBL3961628 | 0.85 | DRD2 (0.54) | DRD2DRD3CYP26A1CA1CA2 | |
| SCHEMBL23343811 | 0.85 | DRD2 (0.54) | DRD2DRD3CYP26A1CA1CA2 | |
| SCHEMBL5713209 | 0.84 | CYP1A2 (0.58) | DRD2DRD3CYP26A1CA1CA2 | |
| SCHEMBL4000915 | 0.83 | DRD2 (0.58) | DRD2DRD3CA1CA2ACHE | |
| SCHEMBL8765765 | 0.83 | DRD2 (0.58) | DRD2DRD3CA1CA2ACHE | |
| SCHEMBL4000913 | 0.83 | DRD2 (0.58) | DRD2DRD3CA1CA2ACHE | |
| SCHEMBL7948432 | 0.82 | DRD2 (0.48) | DRD2DRD3CYP26A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3475262-B1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASE, CARDIOVASCULAR DISEASES AND FIBROTIC DISORDERS | BOEHRINGER INGELHEIM INT (DE) | 2021-03-24 | — | — | EP | disclosed |
| US-10858342-B2 | Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-12-08 | — | — | US | disclosed |
| US-20200109131-A1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASES, CARDIOVASCULAR DISEASES AND FIBROTIC DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-09 | — | — | US | disclosed |
| US-6265398-B1 | INSECTICIDES, FUNGICIDES, ANTIFERTILITY AGENTS | HOECHST SCHERING AGREVO GMBH (DE) | 2001-07-24 | — | — | US | disclosed |
| EP-0898565-A1 | SUBSTITUTED PYRIDINES/PYRIMIDINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS PEST CONTROL AGENTS | Hoechst Schering AgrEvo GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997038979-A1 | SUBSTITUTED PYRIDINES/PYRIMIDINES, PROCESS FOR THEIR PRODUCTION AND THEIR USE AS PEST CONTROL AGENTS | HOECHST SCHERING AGREVO GMBH (DE) | 1997-10-23 | — | — | WO | disclosed |
| US-3984464-A | ANTIARRHYTHMIA AGENTS | A. CHRISTIAENS SOCIETE ANONYME (BE) | 1976-10-05 | — | — | US | disclosed |
| US-3943172-A | ANTIARRHYTHMIA | A. CHRISTIAENS, SOCIETE ANONYME (BE) | 1976-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10858342-B2 | Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases | REN, AGTR1, AGTR2 | DRD2 3287/4885DRD3 2933/4885CYP26A1 840/4885 |
| US-20200109131-A1 | BICYCLIC IMIDAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF RENAL DISEASES, CARDIOVASCULAR DISEASES AND FIBROTIC DISEASES | REN, AGTR1, AGTR2 | DRD2 3287/4885DRD3 2933/4885CYP26A1 840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.