SCHEMBL7958295

SCHEMBL7958295

FC(F)(F)c1ccccc1-c1[c]cc(Cl)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 6/20 0.39
TRPA1 O75762 2/20 0.39
TRPM8 Q7Z2W7 1/20 0.39
TRPV1 Q8NER1 1/20 0.39
CYP3A4 P08684 5/20 0.38
ALOX15 P16050 3/20 0.38
CYP2C19 P33261 3/20 0.38
HSD17B10 Q99714 3/20 0.38
CYP2D6 P10635 2/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPK1 P28482 2/20 0.38
SCN9A Q15858 1/20 0.38
NOTUM Q6P988 2/20 0.37
CYP1A2 P05177 4/20 0.37
TDP1 Q9NUW8 2/20 0.37
USP1 O94782 1/20 0.36
WDR48 Q8TAF3 1/20 0.36
TSHR P16473 1/20 0.35
HIF1A Q16665 1/20 0.35
PDK2 Q15119 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7972200 0.71 KIF11 (0.40) TRPV1NOTUM
SCHEMBL7972246 0.71 CYP1A2 (0.38) ALDH1A1CYP1A2TDP1TSHR
SCHEMBL7972131 0.70 SCN2A (0.44) CYP3A4HSD17B10ALDH1A1NOTUMCYP1A2
SCHEMBL9903469 0.69 NOTUM (0.46) HSD11B1TRPA1TRPM8TRPV1SCN9A
SCHEMBL17436292 0.68 TRPA1 (0.45) HSD11B1TRPA1TRPM8TRPV1CYP3A4
SCHEMBL30097936 0.68 TRPA1 (0.45) HSD11B1TRPA1TRPM8TRPV1CYP3A4
SCHEMBL28619486 0.67 HSD11B1 (0.56) HSD11B1TRPA1TRPM8TRPV1SCN9A
SCHEMBL7968781 0.66 HTT (0.34) HSD17B10
SCHEMBL197671 0.66 HSD11B1 (0.56) HSD11B1TRPA1TRPM8TRPV1CYP3A4
SCHEMBL11158898 0.66 AKR1C3 (0.49) HSD11B1TRPA1TRPM8TRPV1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2001017965-A2 CYANOPIPERIDINES AS PESTICIDES SYNGENTA PARTICIPATIONS AG (CH) 2001-03-15 WO disclosed