Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | HTR4 | Q13639 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965110 | 0.84 | RAB9A (0.55) | KMT2ANPC1ALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL7958855 | 0.79 | NPY1R (0.51) | HTR4ALDH1A1KDM4ETSHRHSD17B10 | |
| SCHEMBL6746510 | 0.76 | P2RX7 (0.48) | P2RX7HTR4KMT2ANPC1KDM4E | |
| SCHEMBL1020686 | 0.75 | P2RX7 (0.55) | P2RX7HTR4KMT2ANPC1KDM4E | |
| SCHEMBL7046652 | 0.75 | P2RX7 (0.47) | P2RX7HTR4KMT2ANPC1KDM4E | |
| SCHEMBL7959114 | 0.74 | SMN1; SMN2 (0.50) | NPC1ALDH1A1KDM4EMAPTNPY1R | |
| SCHEMBL7958725 | 0.74 | ALDH1A1 (0.55) | KMT2ANPC1ALDH1A1KDM4EMEN1 | |
| SCHEMBL7959187 | 0.73 | NPY1R (0.56) | KMT2AALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL7046082 | 0.72 | P2RX7 (0.44) | P2RX7HTR4KMT2ANPC1KDM4E | |
| SCHEMBL1018632 | 0.72 | P2RX7 (0.73) | P2RX7HTR4KMT2ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6245761-B1 | NERVOUS SYSTEM, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-06-12 | — | — | US | disclosed |
| CN-1173867-A | Indolyl neuropeptide Y receptor antagonists | LILLY CO ELI (US) | 1998-02-18 | — | — | CN | disclosed |
| EP-0789688-A4 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-11-19 | — | — | EP | disclosed |
| EP-0789688-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-08-20 | — | — | EP | disclosed |
| WO-1997009308-A1 | INDOLYL NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-03-13 | — | — | WO | disclosed |