Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823757 | 0.82 | LMNA (0.52) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL31621879 | 0.82 | LMNA (0.52) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL3331532 | 0.81 | CHRNA3 (0.49) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL377567 | 0.79 | CYP3A4 (0.52) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL1432110 | 0.79 | ACHE (0.59) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL1824842 | 0.78 | LMNA (0.47) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL311973 | 0.76 | KDM4E (0.67) | LMNAKDM4EMAPTCYP3A4PKM | |
| SCHEMBL26117384 | 0.76 | LMNA (0.46) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL874302 | 0.76 | LMNA (0.54) | LMNAKDM4EMAPTCYP3A4MEN1 | |
| SCHEMBL24436689 | 0.76 | CYP3A4 (0.56) | LMNAKDM4EMAPTCYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |