Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7960161 | 0.85 | CCR2 (0.53) | CCR2DRD2MCHR1 | |
| SCHEMBL7967897 | 0.83 | GLA (0.44) | ADRA1DADRA1AADRA1BKMT2ADRD2 | |
| SCHEMBL7961258 | 0.82 | POLB (0.44) | KMT2ADRD2SLC6A4MCHR1 | |
| SCHEMBL7957582 | 0.81 | OPRL1 (0.45) | CCR2ADRA1DADRA1AADRA1BOPRL1 | |
| SCHEMBL7961236 | 0.81 | CCR2 (0.46) | CCR2ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7957650 | 0.81 | ADRA1A (0.56) | ADRA1DADRA1AADRA1BDRD2MCHR1 | |
| SCHEMBL7963985 | 0.81 | DRD2 (0.52) | CCR2ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7949578 | 0.79 | DRD2 (0.46) | CCR2ADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL7949574 | 0.79 | DRD2 (0.46) | CCR2OPRL1OPRM1OPRK1DRD2 | |
| SCHEMBL7964064 | 0.78 | CCR2 (0.48) | CCR2ADRA1DADRA1AADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |