Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 3/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 6/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7949574 | 0.91 | DRD2 (0.46) | OPRL1OPRM1OPRK1HTR1ACCR2 | |
| SCHEMBL7957071 | 0.85 | DRD2 (0.54) | HTR1ACCR2DRD2DRD3DRD4 | |
| SCHEMBL7959645 | 0.83 | CCR3 (0.42) | HTR1ACCR2DRD2DRD3CCR3 | |
| SCHEMBL7960161 | 0.82 | CCR2 (0.53) | HTR1ACCR2DRD2DRD3DRD4 | |
| SCHEMBL7957585 | 0.81 | KMT2A (0.48) | OPRL1OPRM1OPRK1ADRA1BHTR1A | |
| SCHEMBL7957632 | 0.81 | CCR2 (0.42) | CCR2DRD2DRD3DRD4SMN1; SMN2 | |
| SCHEMBL7961177 | 0.81 | OPRL1 (0.44) | OPRL1ADRA1BCCR2DRD2ADRA1D | |
| SCHEMBL7961256 | 0.81 | CCR2 (0.39) | OPRL1OPRM1OPRK1ADRA1BCCR2 | |
| SCHEMBL7949578 | 0.81 | DRD2 (0.46) | ADRA1BHTR1ACCR2DRD2DRD3 | |
| SCHEMBL7964064 | 0.80 | CCR2 (0.48) | ADRA1BHTR1ACCR2DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |