Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 11/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963813 | 0.93 | ADRA1A (0.47) | CCR2ADRA1ADRD2ADRA1BADRA1D | |
| SCHEMBL7960161 | 0.88 | CCR2 (0.53) | CCR2DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL7949578 | 0.86 | DRD2 (0.46) | CCR2ADRA1ADRD2ADRA1BADRA1D | |
| SCHEMBL7963985 | 0.86 | DRD2 (0.52) | CCR2ADRA1ADRD2ADRA1BADRA1D | |
| SCHEMBL7961177 | 0.84 | OPRL1 (0.44) | CCR2ADRA1ADRD2ADRA1BADRA1D | |
| SCHEMBL7964065 | 0.84 | DRD2 (0.53) | CCR2ADRA1ADRD2DRD3 | |
| SCHEMBL7961375 | 0.82 | SLC6A4 (0.54) | ADRA1ADRD2ADRA1BADRA1DADRA2A | |
| SCHEMBL7957650 | 0.81 | ADRA1A (0.56) | ADRA1ADRD2ADRA1BADRA1DHRH1 | |
| SCHEMBL7961236 | 0.81 | CCR2 (0.46) | CCR2ADRA1ADRD2ADRA1BADRA1D | |
| SCHEMBL7957582 | 0.80 | OPRL1 (0.45) | CCR2ADRA1ADRD2ADRA1BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |