SCHEMBL7962215

SCHEMBL7962215

Bc1ccc2c(c1)C(=O)CCCO2

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.40
MAOA P21397 3/20 0.40
CLK1 P49759 1/20 0.36
DYRK1A Q13627 1/20 0.36
DYRK1B Q9Y463 1/20 0.36
CYP11B2 P19099 3/20 0.35
GRM5 P41594 4/20 0.35
NOTUM Q6P988 1/20 0.35
FABP6 P51161 1/20 0.34
MAPT P10636 1/20 0.34
HTR1A P08908 1/20 0.33
SLC6A4 P31645 1/20 0.33
CTNNB1 P35222 2/20 0.33
WNT3A P56704 2/20 0.33
NPSR1 Q6W5P4 2/20 0.32
NPC1 O15118 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
NFKB1 P19838 1/20 0.32
RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16789730 0.89 MAOB (0.50) MAOBMAOAGRM5FABP6HTR1A
SCHEMBL2628149 0.86 MAOB (0.51) MAOBMAOAGRM5NPSR1NPC1
SCHEMBL1484962 0.79 FABP6 (0.55) MAOBMAOACYP11B2GRM5NOTUM
SCHEMBL989569 0.79 PBRM1 (0.47) MAOBMAOAMAPTHTT
SCHEMBL8019602 0.79 MAOA (0.60) MAOBMAOACLK1DYRK1ADYRK1B
SCHEMBL1181902 0.79 CTSL (0.46) MAOBMAOAGRM5NOTUMNPSR1
SCHEMBL6205990 0.79 CASP1 (0.44) MAOBMAOACLK1DYRK1ADYRK1B
SCHEMBL13464653 0.78 HSD17B10 (0.44) MAOBMAOANOTUMMAPTNPC1
SCHEMBL7605645 0.77 ALDH1A1 (0.49) MAOBMAOAGRM5MAPTCTNNB1
SCHEMBL8029261 0.76 NPC1 (0.52) MAOBCLK1DYRK1ADYRK1BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010021680-A2 INHIBITORS OF BETA-SECRETASE VITAE PHARMACEUTICALS, INC. (US) 2010-02-25 WO disclosed