Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953287 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4ENPSR1HTTUSP2 | |
| SCHEMBL7962698 | 0.84 | L3MBTL1 (0.46) | SMN1; SMN2KDM4EUSP2MAPK1HSD17B10 | |
| SCHEMBL7962210 | 0.83 | TP53 (0.56) | SMN1; SMN2KDM4EMAPK1MAPTPOLB | |
| SCHEMBL7962748 | 0.83 | PDE10A (0.39) | MAPTPDE10AHTR1A | |
| SCHEMBL7962982 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ENPSR1HTTUSP2 | |
| SCHEMBL7962741 | 0.82 | PDE10A (0.42) | HTTMAPTPDE10A | |
| SCHEMBL27193282 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4ENPSR1HTTUSP2 | |
| SCHEMBL7200720 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4ENPSR1HTTUSP2 | |
| Sulfuric Acid SCHEMBL7968960 | 0.78 | ADORA2A (0.39) | SMN1; SMN2KDM4EPOLBPRMT5WDR77 | |
| SCHEMBL7965117 | 0.77 | CYP1A2 (0.58) | SMN1; SMN2NPSR1HTTUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |