Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953284 | 0.87 | PDE10A (0.40) | PDE10ACYP3A4DRD3DRD2OPRM1 | |
| SCHEMBL7962207 | 0.84 | ALDH1A1 (0.43) | DRD3DRD2OPRM1OPRD1OPRK1 | |
| SCHEMBL7962696 | 0.84 | LTA4H (0.35) | OPRM1OPRD1OPRK1OPRL1NPC1 | |
| SCHEMBL7962746 | 0.82 | SMN1; SMN2 (0.47) | PDE10AMAPTHTT | |
| SCHEMBL7962978 | 0.81 | PPARG (0.39) | PDE10AOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7962748 | 0.81 | PDE10A (0.39) | PDE10ACYP3A4DRD3DRD2OPRL1 | |
| SCHEMBL7200716 | 0.78 | KDM4E (0.38) | DRD3OPRM1OPRD1OPRK1OPRL1 | |
| Sulfuric Acid SCHEMBL7968955 | 0.78 | THRB (0.36) | DRD3DRD2OPRM1HTT | |
| SCHEMBL7965112 | 0.77 | LMNA (0.39) | OPRM1OPRD1NPC1MAPTRAB9A | |
| Heptanoate SCHEMBL7966354 | 0.74 | LTA4H (0.38) | DRD3DRD2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |