Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 5/20 | 0.44 |
| ▸ | CCR2 | P41597 | 5/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7957632 | 0.88 | CCR2 (0.42) | CCR2DRD2 | |
| SCHEMBL7964064 | 0.84 | CCR2 (0.48) | CCR2DRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL7949578 | 0.83 | DRD2 (0.46) | CCR2DRD2ADRA1AMCHR1ADRA1D | |
| SCHEMBL7961179 | 0.83 | DRD2 (0.47) | OPRL1CCR2DRD2 | |
| SCHEMBL7960161 | 0.83 | CCR2 (0.53) | CCR2DRD2MCHR1 | |
| SCHEMBL7963813 | 0.82 | ADRA1A (0.47) | CCR2DRD2ADRA1AADRA1DADRA1B | |
| SCHEMBL7949574 | 0.81 | DRD2 (0.46) | OPRL1CCR2DRD2 | |
| SCHEMBL7957582 | 0.81 | OPRL1 (0.45) | OPRL1CCR2DRD2ADRA1AADRA1D | |
| SCHEMBL7959645 | 0.79 | CCR3 (0.42) | CCR2DRD2 | |
| SCHEMBL7961470 | 0.79 | DRD2 (0.49) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |