Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963490 | 0.89 | LMNA (0.46) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| SCHEMBL7964136 | 0.84 | GAA (0.52) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| SCHEMBL7957361 | 0.84 | DRD2 (0.48) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| Hydrochloric Acid SCHEMBL8570980 | 0.83 | DRD2 (0.47) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| SCHEMBL7959422 | 0.82 | DRD2 (0.44) | HTR1AHTR2ACHRM2ADRA2AADRA2B | |
| SCHEMBL7961353 | 0.82 | HTR1A (0.47) | HTR1AHTR2ACHRM2ADRA2AADRA2B | |
| SCHEMBL7957664 | 0.80 | KDM4E (0.51) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| SCHEMBL7960165 | 0.79 | PKM (0.52) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| SCHEMBL7959264 | 0.79 | LMNA (0.53) | PKMHTR1AHTR2ACHRM2ADRA2A | |
| SCHEMBL7959113 | 0.79 | L3MBTL1 (0.41) | PKMHTR1AHTR2ACHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |