Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.45 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963844 | 0.89 | LMNA (0.45) | PKMCHRM2HTR1AADRA2AADRA2B | |
| SCHEMBL7959708 | 0.84 | DRD2 (0.55) | HTR1AHTR2ASLC6A4ADRA1ADRD3 | |
| SCHEMBL7959714 | 0.83 | GAA (0.50) | PKMCHRM2HTR1AADRA2AADRA2B | |
| SCHEMBL7957105 | 0.83 | DRD2 (0.46) | CHRM2HTR1AADRA2AADRA2BADRA1D | |
| SCHEMBL7959533 | 0.81 | DRD2 (0.48) | CHRM2HTR1AADRA2AADRA2BADRA1D | |
| SCHEMBL7961346 | 0.81 | HSD11B1 (0.50) | CHRM2HTR1AADRA2AADRA2BADRA1D | |
| SCHEMBL7957371 | 0.80 | LMNA (0.52) | HTR1AHTR2AHTR2CSLC6A4DRD3 | |
| SCHEMBL7963703 | 0.79 | HSD11B1 (0.41) | CHRM2HTR1AADRA2AADRA2BADRA1D | |
| SCHEMBL7964092 | 0.79 | PKM (0.53) | PKMCHRM2HTR1AADRA2AADRA2B | |
| SCHEMBL7959210 | 0.78 | DRD2 (0.45) | CHRM2HTR1AADRA2AADRA2BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |