Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.43 |
| ▸ | CCR1 | P32246 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965175 | 0.88 | OPRL1 (0.47) | OPRL1OPRM1CCR1HTR1ADRD2 | |
| SCHEMBL7965119 | 0.86 | OPRM1 (0.39) | OPRL1OPRM1CCR1HTR1ADRD2 | |
| SCHEMBL7963819 | 0.85 | MAOA (0.46) | OPRM1CCR1HTR1ADRD2DRD4 | |
| SCHEMBL7953964 | 0.84 | HTR1A (0.40) | OPRL1OPRM1HTR1ADRD2HTR2A | |
| SCHEMBL7953354 | 0.84 | ALPL (0.36) | OPRL1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7969555 | 0.84 | OPRL1 (0.45) | OPRL1OPRM1CCR1HTR1AOPRD1 | |
| SCHEMBL7953304 | 0.84 | OPRL1 (0.38) | OPRL1OPRM1HTR1A | |
| SCHEMBL7964392 | 0.84 | CYP1A2 (0.58) | CYP1A2CYP2D6 | |
| SCHEMBL7200725 | 0.82 | OPRL1 (0.41) | OPRL1OPRM1CCR1HTR1AOPRD1 | |
| SCHEMBL7966030 | 0.82 | ABCB1 (0.38) | OPRL1OPRM1HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |