Sugi Predict

Sugi Predict / Compounds / SCHEMBL7964524

SCHEMBL7964524

SCHEMBL7964524

CN1CCC(c2noc3cc(F)ccc23)CC1

nearest known ligand 0.75

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 6/20 0.75
▸ SLC6A4 P31645 1/20 0.75
▸ ACHE P22303 2/20 0.73
▸ HTR2A P28223 7/20 0.60
▸ KCNH2 Q12809 5/20 0.60
▸ HTR1A P08908 3/20 0.60
▸ HRH3 Q9Y5N1 3/20 0.60
▸ DRD3 P35462 3/20 0.60
▸ HTR2C P28335 2/20 0.60
▸ ADRA1A P35348 2/20 0.60
▸ HRH1 P35367 2/20 0.60
▸ HTR6 P50406 2/20 0.60
▸ HTR7 P34969 3/20 0.58
▸ SCD O00767 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1545611 0.88 ACHE (0.93) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL13409684 0.86 ACHE (0.69) DRD2SLC6A4ACHEHTR2AHTR1A
SCHEMBL18432239 0.85 DRD2 (0.82) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL13898738 0.85 DRD2 (0.67) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL13525309 0.84 HTR2A (0.56) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL7906259 0.83 DRD2 (0.54) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL7722977 0.83 ACHE (0.80) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL793025 0.83 ACHE (0.80) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL8347543 0.83 DRD2 (0.64) DRD2SLC6A4ACHEHTR2AKCNH2
SCHEMBL8346058 0.83 DRD2 (0.64) DRD2SLC6A4ACHEHTR2AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230203007-A1 PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS X-CHEM GLOBAL HQ 2023-06-29 — — US disclosed
US-20230203007-A1 PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS X-CHEM GLOBAL HQ 2023-06-29 — — US disclosed
US-10414771-B2 Compounds useful for inhibiting metastasis from cancer and methods using same DREXEL UNIVERSITY (US) 2019-09-17 — — US disclosed
US-20180099972-A1 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same UNIV DREXEL (US) 2018-04-12 — — US disclosed
US-20180099972-A1 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same UNIV DREXEL (US) 2018-04-12 — — US disclosed
US-9856260-B2 Compounds useful for inhibiting metastasis from cancer and methods using same DREXEL UNIVERSITY (US) 2018-01-02 — — US disclosed
EP-2714687-B1 PROCESS FOR THE PREPARATION OF PALIPERIDONE CIPLA LTD (IN) 2017-02-15 — — EP disclosed
US-20160264587-A1 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same UNIV DREXEL (US) 2016-09-15 — — US disclosed
US-9375474-B2 Compounds useful for inhibiting metastasis from cancer and methods using same DREXEL UNIVERSITY (US) 2016-06-28 — — US disclosed
EP-2235009-B1 SYNTHESIS OF PALIPERIDONE SYNTHON BV (NL) 2013-10-30 — — EP disclosed
WO-2010003702-A1 SYNTHESIS OF PALIPERIDONE SYNTHON B.V. (NL) 2010-01-14 — — WO disclosed
WO-2009074333-A1 SYNTHESIS OF PALIPERIDONE SYNTHON B.V. (NL) 2009-06-18 — — WO disclosed
US-20090156810-A1 SYNTHESIS OF PALIPERIDONE SYNTHON BV (NL) 2009-06-18 — — US disclosed
US-20090156810-A1 SYNTHESIS OF PALIPERIDONE SYNTHON BV (NL) 2009-06-18 — — US disclosed
EP-1308439-B1 PROLINE DERIVATIVES AND USE THEREOF AS DRUGS MITSUBISHI TANABE PHARMA CORP (JP) 2008-10-15 — — EP disclosed
WO-2008108957-A2 PIPERIDINYL-PIPERIDINE AND PIPERAZINYL-PIPERIDINE FOR USE IN THE TREATMENT OF DIABETES OR PAIN SCHERING CORPORATION (US) 2008-09-12 — — WO disclosed
US-20080119487-A1 NOVEL NON-IMIDAZOLE COMPOUNDS SCHERING CORPORATION 2008-05-22 — — US disclosed
US-20080119487-A1 NOVEL NON-IMIDAZOLE COMPOUNDS SCHERING CORPORATION 2008-05-22 — — US disclosed
US-7300941-B2 Non-imidazole compounds SCHERING CORPORATION (US) 2007-11-27 — — US disclosed
US-7300941-B2 Non-imidazole compounds SCHERING CORPORATION (US) 2007-11-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180099972-A1 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same CX3CR1, CCL2, CCR5 DRD2 2074/4885SLC6A4 1587/4885ACHE 852/4885
US-10414771-B2 Compounds useful for inhibiting metastasis from cancer and methods using same CX3CR1, CCL2, CCR5 DRD2 2074/4885SLC6A4 1587/4885ACHE 852/4885
US-20230203007-A1 PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS SCN1A, SCN3A, SCN2A DRD2 2816/4885SLC6A4 208/4885ACHE 439/4885
US-20090156810-A1 SYNTHESIS OF PALIPERIDONE ACOX1, ALOX15B, ALOX15 DRD2 1765/4885SLC6A4 3564/4885ACHE 4761/4885
US-20160264587-A1 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same CX3CR1, CCL2, CCR5 DRD2 2074/4885SLC6A4 1587/4885ACHE 852/4885
US-20080119487-A1 NOVEL NON-IMIDAZOLE COMPOUNDS HRH2, HRH1, HRH4 DRD2 1492/4885SLC6A4 3338/4885ACHE 1083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.